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Estudos de medicamentos biosimilares
(2010-09-01)
In Brazil, the registration of new drugs is carried out only when the regulatory agency (Anvisa, acronym in Portuguese) is fully satisfied with the evidence of their quality, efficacy and safety, presented by a pharmaceutical ...
Pharmacokinetic Profile of A New Diclofenac Prodrug without Gastroulcerogenic Effect
(2013-03-01)
Gastrotoxicity is a major problem for long-term therapy with non-steroidal anti-inflammatory drugs (NSAIDs). DICCIC (1-(2,6-dichlorophenyl)indolin-2-one) is a new diclofenac prodrug, which has proven anti-inflammatory ...
Preparation and characterization of poly(ε-caprolactone) nanospheres containing the local anesthetic lidocaine
(2013-01-01)
The objective of this work was to develop a modified release system for the local anesthetic lidocaine (LDC), using poly(ε-caprolactone) (PCL) nanospheres (NSs), to improve the pharmacological properties of the drug when ...
Bioactive guanidine alkaloids from Pterogyne nitens
(1995-12-01)
Bioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C ...
Molecular modeling databases: A new way in the search of protein targets for drug development
(2007-01-01)
DBMODELING is a relational database of annotated comparative protein structure models and their metabolic, pathway characterization. It is focused on enzymes identified in the genomes of Mycobacterium tuberculosis and ...
Advances in sickle cell disease treatment: From drug discovery until the patient monitoring
(2011-04-01)
Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. ...
Amphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compounds
(2007-01-10)
The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results ...